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Makowicki said GLP-1 drugs combined with weight-loss surgery helped her change her life: Shes had knee-replacement surgery and lost over 200 pounds

However, despite affinity, albeit lower, of tirzepatide for the GLP-1 receptor, tirzepatide had no effect on body weight, food intake, fasting insulin, endogenous glucose production and insulin-stimulated glucose uptake in skeletal muscle and subcutaneous white adipose tissue of GLP-1 receptor knockout mice [89]

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